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Our research focuses not only on development but also on science, that is, on testing the efficacy, safety and quality of our treatment methods. We have more than 25 scientific studies completed or underway, many of which have been published in top medical journals.


Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study. (2019)

Study on the effects of the low-fat ketogenic diet on the gut microflora and its restitution by using probiotics in obese patients in weight loss treatment with the PnK Method. The results are published in Molecular Nutrition & Food Research.

Carolina Gutiérrez‐Repiso, Carmen Hernández‐García, José Manuel García‐Almeida, Diego Bellido Gracia, María Martín‐Núñez, Lidia Sánchez‐Alcoholado, Juan Alcaide‐Torres, Ignacio Sajoux, Francisco Tinahones, Isabel Moreno‐Indias

ProKal 12 Month Study. Comparison Of A Very Low-calorie Ketogenic Diet With A Standard Low-calorie Diet In The Treatment Of Obesity. (2014)

This 12-month interim report demonstrates the efficacy and safety of PronoKal Group® treatments in weight reduction among obese patients who follow a ketogenic diet according to our protocol and those who follow a low-calorie diet. Published in the journal Endocrine.

Bellido D., Casanueva F.F., Crujeiras A.B., Goday A., Moreno B., Saavedra D., Sajoux I.
See study

ProKal 24 Months Study. Obesity Treatment By Very Low-Calorie Ketogenic Diet At Two Years: Reduction In Visceral Fat And On The Burden Of Disease. (2016)

A 2-year study demonstrating the efficacy and safety of PronoKal Group® treatments in weight reduction among obese patients who follow a ketogenic diet according to our protocol and those who follow a low-calorie diet. Published in the journal Endocrine.

Moreno B., Crujeiras A. B., Bellido D., Sajoux I., Casanueva F. F.

CetoPnK Study. Body Composition Changes After Very Low Calorie-Ketogenic Diet In Obesity Evaluated By Three Standardized Methods. (2016)

The study analyses changes in the body composition in obese patients treated with a ketogenic diet according to the PronoKal Group® protocol, measured using three different methodologies (BIA, DXA and ADP). The results were published in The Journal of Clinical Endocrinology & Metabolism (JCEM).

Gomez-Arbelaez D., Bellido D., Castro AI., Ordoñez- Mayan L., Carreira J., Galban C., Martinez-Olmos M.A., Crujeiras A.B., Sajoux I., Casanueva F.F.
See study

PnKLipoinflammation Study. Effect Of DHA Supplementation In A Very Low-Calorie Ketogenic Diet In The Treatment Of Obesity: A Randomized Clinical Trial. (2016)

Comparative, randomized, controlled clinical trial to evaluate the resolution of chronic inflammation associated with obesity in patients undergoing a weight loss programme with the PronoKal Group® ketogenic diet, as well as the impact of DHA on the resolution of lipoinflammation (implicated in the development of metabolic diseases, such as cardiovascular disease and diabetes). The results have been published in Endocrine.

de Luis D, Domingo JC, Izaola O, Casanueva FF, Bellido D, Sajoux
See study

Promesa Study. Efficacy and Safety of the Application of a Very Low Calorie Diet and Subsequent Dietary Re-education Through the PronoKal Method® for the Treatment of Excess Weight. (2014)

Study of the effectiveness and safety of PronoKal Group® treatments in controlled weight loss in overweight and obese patients.

Fondevila J., Martínez-Riquelme A., Sajoux I.
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Systems Biology and Nutrition. Positive Effects of a Protein-Rich Ketogenic Diet on Patients with Type 2 Diabetes, From Clinical Evidence to Molecular Base. (2010)

Positive effects of a ketogenic diet rich in proteins in patients with type 2 diabetes, from clinical evidence to the molecular basis. This study explains why ketosis can work with the PronoKal Method® in patients with type 2 diabetes. Published in the journal Nutrition & Metabolism.

Coma M., Farrés J., Fondevila J., Mas J.M., Sajoux I.

Revealing The Molecular Relationship Between Type 2 Diabetes And The Metabolic Changes Induced By A Very Low-Carbohydrate Low-Fat Ketogenic Diet. (2010)

Aloy P., Coma M., Farrés J., Fondevila J., Mas J.M., Naval J., Pujol A., Ruiz J.L.

Effectiveness of the PronoKal Method® for Losing Weight and Reducing Abdominal Fat. (2014)

Losa López J., Lurueña Sánchez L.F., Sajoux l.

Scientific Evidence On the Efficacy and Safety of the Protein Diet. Protein Diet and Physical Exercise. (2014)

Heredia J.R., Isidro F., Saura J., Segarra V.


This study aims to establish the typicall capillary blood ketone levels in diabetic or prediabetic patients undergoing weight loss using the PronoKal Group® ketogenic diet.


This study is elaborating a detailed description (demographic characteristics, comorbid diseases, habits, etc.) of the profile of the overweight diabetic patient on treatment with the ketogenic diet according to our protocols.


International prospective register of weight loss patients using the ketogenic diet according to PronoKal Group® protocol. An assessment is being performed of weight loss and the changes in factors related to excess weight during treatment.

DiaproKal Study. Protein Diet for Patients With Type 2 Diabetes. (2012)

Clinical study to evaluate the safety of a 4-month intervention using a ketogenic diet versus a low-calorie diet in obese diabetic patients. Weight reduction and effectiveness of metabolic control were also compared. Study presented at the World Diabetes Congress (Dubai, 2011).

Bellido D., Bellón A., Casanueva F., Goday A., Moreno B., Sajoux I.

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